Welcome to PhoenixSongs Biologicals.

PhoenixSongs is a global life science company dedicated to developing and providing novel stem cell-derived model systems for research and drug discovery.

Our stem cell sources include iPS cells and stem cells isolated from human tissues such as liver, brain, biliary tree and umbilical cords. We have a strong IP portfolio and a unique combination of academic expertise and a long history of product development in drug discovery tools.

Our Human/Human™ model represents a fully human-derived system that is well characterized and suited for long-term culture (>30 days), while maintaining cytochrome P450, phase II, and drug transporter gene expression over the course of more than 30 days minimally.

Hepatic Models

PhoenixSongs hepatic models include hepatic stem cells, hepatoblasts or diploid hepatocytes isolated from neonatal livers obtained from federal organ procurement organizations, serum-free hormonally defined medium specific for each lineage stage of growth, differentiation  of the stem cells and maintenance of the mature hepatocytes and on biomatrix isolated from decellularized liver. Each component of the model is sold individually or combined into kits.

PhoenixSongs has exclusive licenses to the hepatic stem cell patent portfolio of over 200 patents from University of North Carolina.

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Human/Human Co-Culture Model 

PhoenixSongs and QPS are jointly offering pre-cultured Human/Human ™ plates to researchers (assay ready) as well as cryopreserved kits and training to allow end users to co-culture in their own laboratories. PhoenixSongs and QPS are positioned and committed to offer the Human/Human ™ model (including media) at a cost that is much less than any co-culture model on the market—essentially at a cost comparable to traditional cryopreserved hepatocytes. This Human/Human™ model is patent pending. 

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Neural Models

PhoenixSongs neural models consist of neural stem cells (NSCs) isolated from the hippocampus and cortex of human brain tissue, hormonally defined serum-free media for each lineage stage for growth and differentiation of the NSCs and maintenance or the mature neurons and reagents needed to care for NSCs.

In addition to NSCs we also offer frozen human neurons differentiated from cortical and hippocampal NSCs. All of our media are application tested for Human, Rat and Mouse NSCs. Each vial of PhoenixSongs NSCs or cryopreserved human neurons come with detailed instructions for expansion, differentiation and maintenance of the mature neural populations. Each component of the model is sold individually or combined in kits.

We do the model validation so all you need to do is test the model in your assays. Order with confidence knowing all components have been qualified for you.

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Pancreatic Model

PhoenixSongs is currently developing a novel pancreatic model that will include human biliary tree stem cells, hormonally defined serum-free lineage stage specific media, and matrix that will guide the differentiation of the biliary tree stem cells into functional beta islets.

PhoenixSongs has co-exclusive licenses to the biliary tree patents from University of North Carolina and La Sapienza.

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Biliary Tree Stem Cells

PhoenixSongs in partnership with Dr. Lola Reid, University of North Carolina is now preparing to make available to the research community our novel biliary tree stem cells (BtSCs). These BtSCs have been shown to differentiate into hepatic and pancreatic fates.  PhoenixSongs has co-exclusive licenses from University of North Carolina and La Sapienza to the IP for this technology.

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Fibrolamellar Cancer Cells 

Fibrolamellar Hepatocellular Carcinoma (FL-HCC) stem cells were isolated from ascites fluid using special culture conditions to select for cancer stem cells (CSCs) and were then transplanted into immunocompromised mice. Tumors formed and were established as a transplantable tumor line, that can be passaged from mouse to mouse. Such a tumor line is referred to as a patient-derived xenograft (PDX) model. 

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Custom Media Program

For more information View Custom Media Program.